LIA is the first national research institute in Germany focusing on biomedical research on human ageing. The mission of LIA is to identify the basic mechanisms that lead to dysfunctions and disease during ageing. The research developed at LIA aims to provide a knowledge basis for the development of future therapies which extend the health span during aging.
The coordinator of LIA in RESETageing is Dr. Alessandro Ori. Ori ́s lab is interested in studying how age and environmental factors affect our organs at the molecular level. The group employs ultrasensitive approaches allowing the quantification of thousands of proteins in tissues as well as in rare cell populations.
The goal of the group is to identify, functionally relevant alterations of the proteome that will enable the researchers to understand the mechanisms of organ deterioration that impact on healthy lifespan. LIA will be further represented in RESETageing project by Dr. Manja Marz who is interested in the study of non-coding RNAs in ageing.